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Perimenopause Menopause symptoms Hormone Replacement Therapy

A guide to explain the Perimenopause, Menopause and HRT

J Boora
J Boora

The Complete Guide

Perimenopause, Menopause & HRT

Everything you need to know, from the first signs to finding what works for you.

πŸ‘©β€βš•οΈ

Julie Boora

Clinical Director, TribElle

For those experiencing symptoms of perimenopause, menopause, or other hormonal changes, you'll know it is not a sudden realisation. It is a slow process of joining the dots together and trying to work out what is causing the changes.

From my own experience, I had hot flushes in my mid 40s but they were fairly mild and I did not think I was old enough to be perimenopausal. I continued with them as a mild inconvenience, but soon I was also suffering from terrible insomnia, brain fog, temperamental moods, and weight gain.

I thought for a long time the issue was insomnia and if I treated that, I would solve all the other problems. It was only when my brain fog became particularly bad that I reached out to my GP. It was the fear of early onset Alzheimer's that finally pushed me to act. With all the other symptoms, I just did not join the dots.

I was not asked to carry out a blood test. It was a phone call, on my way home from London on a busy train, praying the reception did not cut out as we went through tunnels. I started on a treatment of patches containing oestrogen and progesterone. An oestrogen only patch for the first 14 days, followed by a combined oestrogen and progesterone patch for the next 14 days.

These worked okay but caused aches and pains which made my insomnia worse. Determined to figure this out on my own, I stopped the patches, armed myself with magnesium spray and a strict bedtime routine, and saw very little progress.

After a few months off the patches, I went back and asked for an alternative. By this time the weight gain was almost out of control. I was stuck in a cycle of feeling bad, snacking in front of the TV, sleeping badly, and seeing no way out. My GP issued oestrogen gel and progesterone capsules, which I have been using for over a year, and they have been life changing. Spurred on by Davina McCall, I requested testosterone from my GP to try and get my energy back. After a year of waiting to speak to a consultant, I was finally issued testosterone gel.

I share all this because this combination of HRT has enabled me to get out of the rut and find the strength to not only cope in this stage of life but to thrive. I am stronger and fitter than I was in any previous decade of my life.

HRT is not for everyone, and there are some women who can manage their symptoms using other tools. But for me, it has been the help I needed. I really hope this guide helps even just one woman who is struggling to find her mojo, get back on her feet, and feel stronger and ready to take on the world.

At TribElle, we know first hand the struggle to find reliable information or to speak to someone who will listen and help join the dots together, rather than treat symptoms in isolation. This guide is here to give you information on perimenopause, menopause, and HRT options, along with lifestyle advice to work in combination with or without HRT.

Hormones: A Quick Guide

The human body has over 50 different types of hormones. For this guide we focus on the three primary sex hormones and touch on the others that play a role during this stage of life.

🌸

Oestrogen

The primary female sex hormone, mainly produced by the ovaries but also in smaller amounts by the adrenal glands and fat tissue. Its roles include driving sexual and reproductive development, regulating the menstrual cycle, playing a key role in pregnancy and menopause, and affecting the brain, cardiovascular system, and bone health.

The three types:

Estradiol (E2) – most common in women of childbearing age
Estriol (E3) – the primary oestrogen during pregnancy
Estrone (E1) – the primary oestrogen found after menopause

πŸ’œ

Progesterone

Produced mainly by the ovaries after ovulation and by the placenta during pregnancy. Progesterone helps regulate the menstrual cycle and is essential for pregnancy. It prepares the uterine lining for a fertilised egg, suppresses the production of oestrogen after ovulation, and supports pregnancy.

⚑

Testosterone

Though often considered a male hormone, women also produce small but necessary amounts of testosterone in their ovaries and adrenal glands. In women, testosterone contributes to sexual desire and libido, bone and muscle strength, and the regulation of the menstrual cycle.

Other Hormones That Play a Role

FSH

Follicle-stimulating hormone – stimulates the growth of eggs in the ovaries.

LH

Luteinising hormone – triggers ovulation.

Prolactin

Released by the pituitary gland – enables milk production.

hCG

Human chorionic gonadotropin – produced during pregnancy, detected by pregnancy tests.

Cortisol

Stress hormone produced by the adrenal glands.

Thyroxine

Thyroid hormone that controls metabolism.

Insulin

Pancreatic hormone that regulates blood sugar.

Melatonin

Brain hormone that helps regulate sleep.

Perimenopause

This is the period of time before menopause occurs, and you may still be having menstrual periods. During perimenopause, hormone levels fluctuate dramatically, leading to the erratic symptoms associated with this transitional phase. Over time, hormone production from the ovaries gradually declines until it becomes consistently low after menopause.

How Your Hormones Change During Perimenopause

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Oestrogen – Unpredictable

When it spikes: breast tenderness, bloating, weight gain, migraines, and mood swings.

When it dips: hot flashes, night sweats, vaginal dryness, and sleep disturbances.

πŸ’œ

Progesterone – Often the First to Decline

Often starting in the late 30s, progesterone drops as ovulation becomes more irregular. This creates oestrogen dominance, worsening mood swings, anxiety, fatigue, and causing irregular cycles, spotting, and changes in period flow.

🧬

FSH – Rising and Erratic

As the ovaries become less responsive, the brain releases more FSH to try and stimulate egg production. Levels can fluctuate wildly, making a single blood test unreliable during this stage. A consistently high FSH level is a marker of menopause.

⚑

Testosterone – Gradually Declining

Production naturally and gradually decreases with age. Though less abrupt than changes in oestrogen and progesterone, lower testosterone can contribute to reduced libido, lower energy, and brain fog.

Why hormones fluctuate: The hormonal changes during perimenopause are not a steady decline but a turbulent rollercoaster of up-and-down shifts. The symptoms women experience often depend on whether their oestrogen levels are spiking or dipping at any given time. This is a normal and natural part of the transition leading up to menopause.

What Are the Symptoms to Look Out For?

Perimenopause can last anywhere from a few months to several years, with the specific symptoms and their severity varying for each person.

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Menstrual Changes

Irregular periods

The time between periods can become longer or shorter. You might have a period every few weeks or skip one for several months.

Changes in flow

Flow might become unusually heavy or light. Heavy bleeding may include large blood clots and require changing products frequently.

Spotting

Light bleeding or spotting can occur between your usual periods.

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Physical Symptoms

πŸ”₯ Hot flashes & night sweats

Sudden, intense feelings of heat, often with sweating and flushed skin.

😴 Sleep problems

Insomnia is common, often caused by night sweats or hormonal changes affecting sleep regulation.

πŸ’§ Vaginal & bladder issues

Tissues become drier, thinner, and less elastic, leading to pain during sex, itching, and increased risk of infections.

🀯 Headaches & migraines

Those prone to migraines may find them become more frequent or severe.

🦴 Joint & muscle aches

Aches, pains, and stiffness in the joints and muscles are often reported.

βš–οΈ Weight gain & skin changes

Slower metabolism, often leading to weight gain around the abdomen. Skin may become drier; hair may thin.

🧠

Mental & Emotional Symptoms

😀 Mood swings & irritability

A rollercoaster of emotions, from irritability and anxiety to low mood.

🌫️ Brain fog

Problems with memory, concentration, and mental clarity.

😰 Anxiety & depression

Risk increases, especially for those with a history of hormonal mood changes.

πŸ’” Reduced libido

Low sexual desire from a combination of hormonal changes and physical discomfort.

🚨 When to See a Doctor

While these symptoms are a normal part of the perimenopause transition, do consult a healthcare provider if you experience:

⚠️ Very heavy bleeding or bleeding lasting more than 7 days

⚠️ Bleeding between periods or after sex

⚠️ Periods occurring less than 21 days apart

⚠️ Symptoms interfering with your quality of life

Menopause

A woman officially reaches menopause when she has gone 12 consecutive months without a menstrual period. This marks the end of the reproductive years. Afterward she is considered to be in postmenopause for the rest of her life. During this final stage, hormone levels stabilise at a consistently low level, and while some symptoms may subside, new health risks emerge.

Hormones After Menopause

Oestrogen & Progesterone – The ovaries stop producing high levels. This is the primary cause of postmenopausal changes.

FSH – Levels stabilise at a consistently high level after the wild fluctuations of perimenopause.

Testosterone – Continues to decline, but more gradually than oestrogen and progesterone.

Symptoms That May Continue

β€’ Vaginal dryness and atrophy

β€’ Urinary changes and increased UTI risk

β€’ Mood swings, anxiety, brain fog

β€’ Hot flashes and night sweats (for some, these persist for years)

β€’ Drier skin and hair thinning

New Health Risks

Osteoporosis
Oestrogen is crucial for bone density. The sharp decline after menopause accelerates bone loss, significantly increasing the risk of fractures.

Cardiovascular disease
The protective effect of oestrogen on the heart is lost, increasing the risk of heart attack and stroke.

Hormone Replacement Therapy (HRT)

HRT is a treatment used to alleviate symptoms of perimenopause and menopause by replacing the hormones the ovaries produce less of as you age. It is considered a safe and effective treatment for most women.

βœ… What HRT Can Help With

Symptom relief

Hot flashes, night sweats, sleep problems, mood swings, anxiety, and vaginal dryness.

Bone health

Increases oestrogen, reducing the risk of bone thinning and fractures.

Heart health

Starting HRT before age 60 may reduce the risk of heart disease and cardiovascular mortality.

Muscle strength

Can help maintain muscle strength, which commonly decreases during menopause.

Two Main Types of HRT

πŸ’Š

Oestrogen-Only

Recommended for women who have had a hysterectomy (womb removal).

πŸ’ŠπŸ’œ

Combined

Contains oestrogen and progestogen. Essential for women who still have their womb, to protect against womb cancer.

HRT: Forms, Pros & Cons

Form

βœ… Pros

⚠️ Cons

Examples

πŸ’Š Tablets

Convenient daily use. Lowest cost.

May increase blood clot risk. Possible indigestion.

Evorel Conti, Femoston-conti, Kliovance, Elleste Solo, Utrogestan

🩹 Patches

Safer for those at higher blood clot risk. Avoids liver metabolism.

May not stick well on moisturised skin. Can cause skin irritation.

Evorel Conti, Evorel Sequi, Estradot, Estraderm MX

🧴 Gels / Sprays

Absorbed through skin, reducing blood clot risk. Easily adjusted.

Needs daily application. Can transfer to others until dry.

Oestrogel, Sandrena gel, Lenzetto Spray

πŸ’§ Vaginal Oestrogen

Low dose, localised. Safe long-term without progesterone. Minimal systemic absorption.

Only treats local symptoms. May damage condoms or diaphragms.

Vagifem, Gina tablets, Ovestin cream, Estring ring

πŸ”„ IUS (Mirena Coil)

Provides progestogen locally. Also acts as contraception. Lasts up to 5 years.

Requires professional insertion. May cause abdominal pain.

Mirena Coil

⚑ Testosterone Gel

May help low libido. Can improve mood and energy.

Not licensed specifically for women in the UK. Possible acne or hair growth.

Testogel sachets, Tostran pump

πŸŒ€ Tibolone

Mimics oestrogen, progesterone, and testosterone. May improve libido.

Only for postmenopausal women. May not be as effective as combined HRT.

Livial

πŸ†• Elinzanetant

Non-hormonal option. Calms overactive brain signals controlling body temperature.

NICE review pending for NHS. Only treats hot flashes and night sweats.

Lynkuet

⚠️ Important Considerations

Breast cancer risk: Combined HRT may slightly increase the risk, which increases with duration of use. The risk is lower with oestrogen-only HRT.

Individualised treatment: The choice of HRT type and dosage should be made in consultation with a healthcare professional, considering your symptoms, medical history, and risk profile.

Stopping HRT: Should be done gradually under medical supervision to minimise the return of symptoms.

Lifestyle Changes That Can Help

Combining healthy lifestyle adjustments with or without HRT can significantly improve the physical and emotional symptoms of perimenopause and menopause.

πŸ₯—

Improve Your Nutrition

Focus on a Mediterranean-style diet with whole grains, fruits, vegetables, nuts, seeds, and healthy fats like olive oil.

Eat foods rich in calcium and vitamin D to protect bone health: milk, yogurt, kale, and fortified products.

Include phytoestrogens in your diet: soy products like tofu and edamame, and flaxseed.

Limit caffeine, alcohol, and spicy foods which can trigger hot flashes.

πŸ‹οΈ

Adapt Your Exercise Routine

Combine aerobic and strength training. Aim for 150 minutes of moderate-intensity aerobic exercise per week.

Do weight-bearing and resistance exercises to maintain bone density and muscle mass: jogging, dancing, lifting weights, yoga.

Try balance and mobility work like yoga, Pilates, or tai chi to reduce the risk of falls.

🧘

Prioritise Stress Management

Practice meditation, mindfulness, and deep-breathing exercises. Even a few minutes a day can help.

Try Cognitive Behavioural Therapy (CBT) to reframe negative thought patterns and develop coping strategies.

Connect with others. Social connections with friends, family, or support groups can help you feel less isolated.

πŸŒ™

Optimise Your Sleep Hygiene

Keep your bedroom cool, dark, and quiet. A room temperature around 18Β°C is often recommended.

Establish a consistent sleep routine. Go to bed and wake up at the same time each day, even on weekends.

Choose light, breathable fabrics for nightwear and bedding to manage night sweats.

πŸ’‘ Consider Professional Support & Alternatives

Non-hormonal medications: Discuss options with the TribElle Clinical Team. Certain antidepressants or other medications may be prescribed by your GP if HRT is not suitable for you.

Herbal supplements: Approach with caution. While some women report benefits from remedies like black cohosh or St John's Wort, scientific evidence is mixed and they can have side effects or interact with other medications.

Other therapies: Acupuncture is one option that some studies suggest can improve hot flashes and quality of life.

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