For women managing genital herpes, choosing between Aciclovir and Valaciclovir can feel confusing. Both are trusted antiviral medications used across the UK, but they differ in convenience, dosing, and long-term use. This guide breaks down the differences in a clear, stigma-free way so you can feel informed.
Herpes is a medical condition, not a moral verdict. Medication is not weakness, it’s self-care.
Both medicines work by slowing down the herpes virus, helping outbreaks heal faster and reducing the severity of symptoms. They do not cure herpes, but they give you back control.
| Medication | Purpose |
|---|---|
| Aciclovir | Shortens outbreaks, helps pain and sores heal faster |
| Valaciclovir | Same effect, but converted by the body into Aciclovir and requires fewer doses |
| Feature | Aciclovir | Valaciclovir |
|---|---|---|
| Doses per day (outbreak) | 3–5 times daily | 2 times daily |
| Convenience | Needs regular reminders | Easier routine |
| Cost (UK) | Usually cheaper | Slightly more expensive |
| NHS Availability | Widely available | Widely available |
| Used for Suppression? | Yes | Yes (more common) |
Valaciclovir may be easier, taken one morning and one evening.
Valaciclovir offers flexibility with fewer doses to carry.
Aciclovir is typically more affordable, especially when obtained on a private prescription.
Both work, but for daily suppression, many UK clinicians prefer Valaciclovir for simplicity.
Start antivirals as soon as tingling or soreness begins, even before blisters.
Typical UK dosing:
| Medication | Typical Outbreak Dose |
|---|---|
| Aciclovir | 400mg 3–5 times daily for 5–10 days |
| Valaciclovir | 500mg twice daily for 5 days |
For women with frequent or emotional distress from outbreaks, daily antiviral suppression may be offered by a GP or sexual health clinic.
| Medication | Typical Suppressive Dose |
|---|---|
| Aciclovir | 400mg twice daily |
| Valaciclovir | 500mg once daily |
Daily treatment can:
Reduce outbreak frequency by up to 80%
Lower the chance of transmission to partners
Restore peace of mind
Most people tolerate both medicines well.
| Common Side Effects | Usually Mild and Temporary |
|---|---|
| Headache | ✔ |
| Nausea | ✔ |
| Stomach upset | ✔ |
| Fatigue | ✔ |
Severe reactions are rare — always seek medical advice if symptoms feel unusual or persistent.
NHS: GPs may prescribe either medication, especially for recurrent or severe herpes.
Sexual Health Clinics: Can provide assessment, diagnosis, and support.
Private Online Pharmacies: Offer both medicines with a prescription, often for convenience or discretion.
There’s no “better” medicine ,only what fits best into your life.
Taking suppressive treatment doesn’t mean things are “worsening.” It means you’re choosing calm, comfort, and control. Your strength is not measured by how much you endure — but how well you care for yourself.
If you're unsure which antiviral is right for you, or whether suppression is appropriate, speaking with a qualified clinician can offer clarity. You never have to make these decisions alone.
Aciclovir and Valaciclovir are tools to help manage genital herpes. What matters most is your comfort, confidence, and peace of mind. The best treatment is the one that helps you live your life, uninterrupted.