---
title: "Ryeqo for Fibroids and Endometriosis: What Women in the UK Need to Know"
description: Discover Ryeqo, a promising treatment for fibroids and endometriosis, addressing women's hormonal health challenges and improving quality of life.
image: https://blog.tribelle.co.uk/hubfs/Home%20Testing%20Blog%20(2)-4.png
---

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Pain Management

# Ryeqo for Fibroids and Endometriosis: What Women in the UK Need to Know

![TribElle Clinical Team](https://blog.tribelle.co.uk/hs-fs/hubfs/Untitled%20design%20(23).png?width=48&height=48&name=Untitled%20design%20(23).png)

 TribElle Clinical Team

May 22, 2026

Reviewed by **Julie Boora**, Superintendent Pharmacist, TribElle Health Ltd (GPhC Reg. 9012688)

 

Women's hormonal health conditions are often underdiagnosed, misunderstood, or dismissed for years before effective treatment is offered. Conditions like **fibroids, endometriosis, heavy menstrual bleeding, pelvic pain, and hormone-related symptoms** can significantly affect quality of life, work, sleep, fertility, mental health, and relationships.

One medication that is gaining increasing attention in women's healthcare is **Ryeqo**. Despite being available in the UK and Europe, many women still do not know what it is, how it works, or who it may help.

This guide explains:

| → What Ryeqo is and what it treats |
| --- |
| → How it works |
| → Potential benefits and risks |
| → The latest evidence-based research |
| → Why women should understand this treatment option |

 

## What is Ryeqo?

Ryeqo is a prescription medication used to treat:

| → Moderate to severe symptoms of uterine fibroids |
| --- |
| → Endometriosis-associated pain |
| → Hormone-related gynaecological symptoms in some women |

It combines three active ingredients:

| Relugolix GnRH receptor antagonist | Estradiol Add-back oestrogen | Norethisterone acetate Add-back progestogen |
| --- | --- | --- |

Quick answer

Ryeqo reduces the production of hormones that drive fibroid growth and endometriosis symptoms, while replacing small amounts of hormones to reduce side effects such as bone density loss and menopausal symptoms.

 

## Why more women should know about Ryeqo

Many women spend years searching for answers before receiving effective treatment for hormone-related conditions. Symptoms are often normalised or dismissed:

| Common dismissed symptoms Heavy bleeding Severe period pain Pelvic pressure and bloating Pain during sex Fatigue and fertility challenges Chronic pelvic pain | Awareness may help avoid Repeated surgeries Long-term unmanaged symptoms Chronic pain progression Reduced quality of life Delayed fertility decisions |
| --- | --- |

 

## How Ryeqo works

Ryeqo belongs to a newer class of medications called **GnRH receptor antagonists**. These reduce the body's production of oestrogen and progesterone — hormones that can worsen fibroid growth, heavy menstrual bleeding, endometriosis lesions, and pelvic inflammation.

However, completely suppressing oestrogen can trigger menopause-like symptoms. To reduce this risk, Ryeqo includes **add-back hormone therapy**, which helps maintain safer hormone levels while still controlling symptoms. This combined approach aims to balance:

| → Symptom reduction |
| --- |
| → Bone protection |
| → Hormonal stability |
| → Improved tolerability compared to older hormone suppression treatments |

 

## Conditions Ryeqo is commonly used for

| Uterine fibroids Non-cancerous growths in or around the uterus that can cause heavy periods, anaemia, pelvic pressure, urinary symptoms, pain, and fertility problems. Ryeqo may help shrink fibroid-related symptoms and reduce menstrual bleeding. | Endometriosis Tissue similar to the uterine lining grows outside the uterus, causing severe pain, fatigue, digestive symptoms, chronic inflammation, and fertility issues. Ryeqo may reduce endometriosis-related pain by lowering oestrogen stimulation. |
| --- | --- |

 

## Evidence-based research on Ryeqo

Research into GnRH antagonists has expanded rapidly as clinicians search for alternatives to surgery and long-term unmanaged hormonal symptoms.

Ryeqo clinical evidence — SPIRIT trials

| → The SPIRIT 1 and SPIRIT 2 phase 3 trials demonstrated that relugolix combination therapy significantly reduced heavy menstrual bleeding in women with uterine fibroids compared to placebo. NEJM, 2021 |
| --- |
| → Over 70% of women in the relugolix combination group achieved reduced menstrual blood loss, with improvements in anaemia, pain, and quality of life |
| → Bone density was better preserved with the add-back combination therapy compared to relugolix alone |

Wider context: advances in women's hormonal health

| → Research into modern hormone-regulating medications demonstrates how targeting neurological and hormonal pathways can improve symptom control while reducing reliance on older treatment models. US FDA |
| --- |
| → Clinical studies involving newer women's health therapies have shown improvements in symptom severity, treatment tolerability, and patient-reported quality of life. US FDA |

 

## Why women's hormonal health needs more attention

Historically, women's health conditions have faced delayed diagnosis, limited research funding, symptom dismissal, under-treatment, and lack of public awareness. Many women with fibroids or endometriosis wait years before diagnosis — affecting physical health, mental wellbeing, career, relationships, and fertility outcomes.

Improving awareness around medications like Ryeqo helps women have more informed conversations with healthcare professionals and explore treatment pathways earlier — before conditions worsen or fertility is compromised.

 

## Potential benefits of Ryeqo

Depending on the individual and condition being treated, possible benefits may include:

| Symptom improvements ✓Reduced heavy bleeding ✓Less pelvic pain ✓Improved daily functioning ✓Reduced need for surgery ✓Better symptom control | Wider wellbeing ✓Better sleep and energy ✓Improved emotional wellbeing ✓Greater confidence ✓Ability to work and exercise ✓Improved quality of life |
| --- | --- |

 

## Important risks and side effects

Like all prescription medications, Ryeqo may not be suitable for everyone. Possible side effects can include:

Possible side effects

| ⚠ Headaches | ⚠ Mood changes |
| --- | --- |
| ⚠ Hot flushes | ⚠ Reduced bone mineral density |
| ⚠ Irregular bleeding | ⚠ Nausea |

Hormone-modulating medications also require careful medical assessment, particularly in women with certain cardiovascular, liver, clotting, or hormone-sensitive conditions. Treatment decisions should always be personalised and discussed with a qualified healthcare professional.

 

## The future of women's hormonal healthcare

The growing visibility of medications like Ryeqo reflects a wider shift in women's healthcare — towards earlier intervention, personalised medicine, non-surgical treatment options, and long-term quality of life outcomes.

Women are becoming more proactive about understanding perimenopause, endometriosis, fibroids, hormone regulation, and menopause symptom management. This shift is helping reduce stigma around reproductive and hormonal health conversations — and driving demand for better, faster, more informed care.

 

## Frequently asked questions about Ryeqo

Is Ryeqo a menopause medication? +

Not exactly. Ryeqo is primarily used for fibroids and endometriosis, but because it affects hormone levels, some women experience menopause-like symptom changes while taking it. The add-back hormones in Ryeqo are designed to minimise these effects.

Does Ryeqo stop periods? +

For some women, Ryeqo may significantly reduce or stop menstrual bleeding during treatment. In clinical trials, the majority of women experienced a meaningful reduction in menstrual blood loss within the first few months.

Can Ryeqo help endometriosis pain? +

Yes. Ryeqo may help reduce hormone-driven inflammation and pain associated with endometriosis by lowering oestrogen levels. Results vary between individuals, and it should always be prescribed and monitored by a healthcare professional.

Is Ryeqo a hormone replacement therapy (HRT)? +

No. Ryeqo is not standard HRT, although it contains small amounts of oestrogen and progestogen (add-back therapy) to help reduce side effects from hormone suppression. It works differently from standard HRT and is prescribed for different conditions.

Can Ryeqo replace surgery? +

In some cases, Ryeqo may reduce symptoms enough to delay or avoid surgery. Whether it can replace surgery depends on the severity of the condition and individual response, and should be assessed with a specialist.

 

## Final thoughts from TribElle

Women deserve greater awareness, faster diagnosis, and more treatment choices when managing hormonal health conditions. Understanding how medications like Ryeqo work can help you have more informed conversations with healthcare professionals — and explore treatment pathways that align with your symptoms, goals, and overall wellbeing.

Read more from TribElle

| [GLP-1 medications and perimenopause weight gain →](https://blog.tribelle.co.uk/perimenopause-and-menopause-weight-gain?hsLang=en) |
| --- |
| [PMOS explained: the science behind the condition →](https://blog.tribelle.co.uk/pcos-explained-beyond-the-cysts?hsLang=en) |
| [GLP-1 weight loss injections: what you need to know →](https://blog.tribelle.co.uk/glp1-weight-loss-guide-uk?hsLang=en) |

### Supporting your health journey. Here's what we stock at TribElle.

| [GLP-1 Support Pack £25](https://tribelle.co.uk/product-details/GLP-1%20Support%20Pack) |
| --- |
| [Perfectil Collagen Skin £39.99](https://tribelle.co.uk/product-details/Perfectil%20Collagen%20Skin%20Drink%20(10)) |
| [Perfectil Collagen Hair £39.99](https://tribelle.co.uk/product-details/Perfectil%20Collagen%20Hair%20Drink%20(10)) |

Sources

| [NEJM (2021) — SPIRIT trials: relugolix combination for uterine fibroids](https://www.nejm.org/doi/full/10.1056/NEJMoa2103569) |
| --- |
| [US FDA — Advances in women's hormonal health treatments](https://www.fda.gov/news-events/press-announcements/fda-approves-novel-drug-treat-moderate-severe-hot-flashes-caused-menopause) |
| [PubMed — Research on neurokinin receptor therapies](https://pubmed.ncbi.nlm.nih.gov/33724119/) |
| [PMC — Phase 2 clinical study on hormonal symptom therapies](https://pmc.ncbi.nlm.nih.gov/articles/PMC7147405/) |

© TribElle Health Ltd · GPhC Registration 9012688 · tribelle.co.uk · This content is for informational purposes only. Always consult a qualified healthcare professional.

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