Aciclovir vs Valaciclovir: Which Works Best for Genital Herpes?

For women managing genital herpes, choosing between Aciclovir and Valaciclovir can feel confusing. Both are trusted antiviral medications used across the UK, but they differ in convenience, dosing, and long-term use. This guide breaks down the differences in a clear, stigma-free way so you can feel informed.

Herpes is a medical condition, not a moral verdict. Medication is not weakness, it’s self-care.

💊 What Do Aciclovir and Valaciclovir Actually Do?

Both medicines work by slowing down the herpes virus, helping outbreaks heal faster and reducing the severity of symptoms. They do not cure herpes, but they give you back control.

🔍 Key Differences at a Glance

🕒 When to Use Each — Real-Life Scenarios

🗓 “I struggle to remember tablets more than twice a day.”

Valaciclovir may be easier, taken one morning and one evening.

💼 “I’m travelling or working long shifts.”

Valaciclovir offers flexibility with fewer doses to carry.

💸 “I want the most cost-effective option.”

Aciclovir is typically more affordable, especially when obtained on a private prescription.

🔁 “I get outbreaks around my period every month.”

Both work, but for daily suppression, many UK clinicians prefer Valaciclovir for simplicity.

📉 Using Medication During an Outbreak (Episodic Treatment)

Start antivirals as soon as tingling or soreness begins, even before blisters.
Typical UK dosing:

🔒 Using Daily Suppression (Long-Term Control)

For women with frequent or emotional distress from outbreaks, daily antiviral suppression may be offered by a GP or sexual health clinic.

Daily treatment can:

• Reduce outbreak frequency by up to 80%

• Lower the chance of transmission to partners

• Restore peace of mind

⚖️ Side Effects — What to Expect

Most people tolerate both medicines well.

Severe reactions are rare — always seek medical advice if symptoms feel unusual or persistent.

🏥 Access in the UK — NHS or Private?

• NHS: GPs may prescribe either medication, especially for recurrent or severe herpes.

• Sexual Health Clinics: Can provide assessment, diagnosis, and support.

• Private Online Pharmacies: Offer both medicines with a prescription, often for convenience or discretion.

There’s no “better” medicine ,only what fits best into your life.

🧠 Needing Medication Is Not Failure

Taking suppressive treatment doesn’t mean things are “worsening.” It means you’re choosing calm, comfort, and control. Your strength is not measured by how much you endure — but how well you care for yourself.

If you're unsure which antiviral is right for you, or whether suppression is appropriate, speaking with a qualified clinician can offer clarity. You never have to make these decisions alone.

💬 Final Thought

Aciclovir and Valaciclovir are tools to help manage genital herpes. What matters most is your comfort, confidence, and peace of mind. The best treatment is the one that helps you live your life, uninterrupted.