Switching from Mounjaro to Wegovy: What You Need to Know

At TribElle, we know that everyone’s weight management journey is unique. Some of our patients start on Mounjaro (Tirzepatide) and later consider switching to Wegovy (Semaglutide)—whether due to cost, supply, personal preference, or clinical reasons.

Key takeaways

If you’re thinking about making the switch, here’s what you need to know.

When switching from Mounjaro (Tirzepatide) to Wegovy, also known as Ozempic (Semaglutide), our clinical team recommends starting Wegovy from the lowest dose (0.25mg) and then working your way up through the titration schedule.

Even though you’ve been on Mounjaro, Semaglutide works differently in the body, and it’s important to follow the step-up protocol for safety and tolerance. This is in line with Wegovy’s licensed guidance and helps minimise the risk of side effects.

👉 How the switch works:

• There’s no washout period needed between Mounjaro and Wegovy.
• Simply take your last dose of Mounjaro as usual.
• On your next scheduled injection day, start Wegovy 0.25mg.

For example, if your last Mounjaro dose was on a Sunday, your first Wegovy dose would be the following Sunday.

Why start from the lowest dose?

Even if you’ve already been taking Mounjaro, Wegovy works differently in the body. That means your system needs time to adjust.

Our clinical team recommends always starting with the lowest Wegovy dose (0.25mg once weekly) and then working up through the licensed titration schedule.

👉 This gradual increase is important because:

• It helps your body tolerate semaglutide safely.
  
  
• It reduces the risk of common side effects like nausea, bloating or changes in bowel habits.
  
  
• It follows Wegovy’s licensed guidance, which is based on extensive clinical trial data.

How the switch works

The good news is there’s no washout period needed between Mounjaro and Wegovy.

Here’s the simple step-by-step:

1. Take your last dose of Mounjaro as usual.
   
   
2. On your next scheduled injection day, begin Wegovy at 0.25mg.
   
   
3. For example, if your last Mounjaro dose was on a Sunday, your first Wegovy dose would be the following Sunday.

From there, you’ll continue with Wegovy’s step-up dosing plan:

• 0.25mg weekly for 4 weeks
  
  
• Then 0.5mg, 1mg, and so on—depending on how you tolerate it and your clinical plan

What to expect when switching

Everyone responds differently. Some patients find the switch smooth, while others notice changes in appetite suppression or side effects as their body adapts.

What’s most important is that you:

• Give your body time to adjust to the new medicine
  
  
• Check in with your prescriber or pharmacist if you’re worried about symptoms
  
  
• Don’t rush the process—slow and steady dosing leads to better long-term results

Switching from Mounjaro to Wegovy is safe and straightforward—but it’s vital to start at 0.25mg and titrate up, even if you were already established on Mounjaro. This protects your safety, keeps side effects manageable, and gives you the best chance of long-term success.

At TribElle, we’re here to support you every step of the way. If you’re considering switching or want to discuss your options, just reach out to our clinical team—we’re happy to guide you.

FAQs on Switching from Mounjaro to Wegovy

Do I need to stop Mounjaro before starting Wegovy?
No. Simply take your last Mounjaro dose as planned, and begin Wegovy on your next scheduled injection day.

Will I lose progress if I start back at 0.25mg?
Not at all. Starting low is about safety, not starting over. Your body already knows how to respond to GLP-1 medicines, and titration helps maintain tolerability.

Can I jump to a higher dose of Wegovy since I was already on Mounjaro?
No. Even if you were on a higher Mounjaro dose, Wegovy acts differently in the body. Skipping steps could increase side effects and is not recommended.

What side effects should I expect?
The most common include nausea, bloating, constipation, or diarrhoea. These usually ease as your body adjusts, especially with gradual titration.

Who should I speak to if I’m unsure?
Contact our clinical team if you have concerns about switching or experience troublesome side effects.